1.
Describe
the various parameter of plasma concentration time profile obtain after a
single dose of a drug administered by extra vascular route. [10]
2.
Discuss
Indications and Protocol for TDM. Discuss application of biopharmaceutics and
pharmacokinetics in controlled release drug delivery system. [10]
3. Differentiate
between linear and nonlinear kinetics. Discuss the different methods to determine km and Vmax. [10]
4.
Discuss
theories of dissolution. Discuss the concepts on various mathematical modeling
of drug release. [10]
5.
Explain
in-vitro in-vivo correlation. Discuss the curve fitting and regression
procedures. [10]
6.
Procainamide is to be administered to a
65kg arrhythmic patient at 500mg tablet every 4 hours. The drug has half-life 3
hr, Vd of 2L/kg and oral availability 0.85.
a)
Calculate the steady state conc. of drug.
b) What change would you recommended
in the dose regimen if the therapeutic range of drug is 4-12 mcg/ml? [10]
7.
A new antibiotic drug was given a single
intravenous bolus of 4mg/kg to a 35-year-old healthy male adult (body weight
75kg). The pharmacokinetics of the plasma drug *concentration-time curve for
this drug fits a one-compartment model. The equation of the curve that best
fits the data is Ct=78e-0.46t. Determine the following (assume units of mcg/ml
for Ct and hr for time);
i)
What is the t1/2?
i)
What is the Vd?
iii)
What is the plasma level of the drug after 4 hours?
iv)
How much drug is left in the body after 4 hours?
v)
Assuming the drug is no longer effective when levels decline to less than
2mcg/mg, when should you administer the next dose? [10]
8. Drug
X is to be administered to a 70 kg patient at a rate of 2 mg/kg every 12 hour
by multiple IM injection. The drug has a half-life of 2.2 hours and Vd, of 0.2
L/kg.
a)
Determine Css,Max, Css,min and Cssavg.
b) If the half-life increases to five hours in renal insufficiency,
what should be the new dose or the new dosing interval? [10]
No comments:
Post a Comment